Nature vs nurture? Find out more in terms of the pediatrics and adolescent athlete.
Sources
- Baltazar-Martins G, Gutiérrez-Hellín J, Aguilar-Navarro M, Ruiz-Moreno C, Moreno-Pérez V, López-Samanes Á, Domínguez R, Del Coso J. Effect of ACTN3 Genotype on Sports Performance, Exercise-Induced Muscle Damage, and Injury Epidemiology. Sports (Basel). 2020 Jul 13;8(7):99. doi: 10.3390/sports8070099. PMID: 32668587; PMCID: PMC7404684.
- De Moor MH, Spector TD, Cherkas LF, Falchi M, Hottenga JJ, Boomsma DI, De Geus EJ. Genome-wide linkage scan for athlete status in 700 British female DZ twin pairs. Twin Res Hum Genet. 2007 Dec;10(6):812-20. doi: 10.1375/twin.10.6.812. PMID: 18179392.
- Ehlert T, Simon P, Moser DA. Epigenetics in sports. Sports Med. 2013 Feb;43(2):93-110. doi: 10.1007/s40279-012-0012-y. PMID: 23329609.
- Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suñer D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, Wu YZ, Plass C, Esteller M. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad SciU S A. 2005 Jul 26;102(30):10604-9. doi: 10.1073/pnas.0500398102. Epub 2005 Jul 11. PMID: 16009939; PMCID: PMC1174919.
- John R, Dhillon MS, Dhillon S. Genetics and the Elite Athlete: Our Understanding in 2020. Indian J Orthop. 2020 Mar 11;54(3):256-263. doi: 10.1007/s43465-020-00056-z. PMID: 32399143; PMCID: PMC7205921.
- Jonsson, H., Magnusdottir, E., Eggertsson, H.P. et al. Differences between germline genomes of monozygotic twins. Nat Genet 53, 27–34 (2021). https://doi.org/10.1038/s41588-020-00755-1
- Kristman VL, Tator CH, Kreiger N et al. Does the apolipoprotein epsilon 4 allele predispose varsity athletes to concussion? A prospective cohort study. Clin. J. Sport Med. 18(4), 322–328 (2008).
-Pickering C, Kiely J. ACTN3: More than Just a Gene for Speed. Front Physiol. 2017 Dec 18;8:1080. doi: 10.3389/fphys.2017.01080. PMID: 29326606; PMCID: PMC5741991.
- Naureen Z, Perrone M, Paolacci S, Maltese PE, Dhuli K, Kurti D, Dautaj A, Miotto R, Casadei A, Fioretti B, Beccari T, Romeo F, Bertelli M. Genetic test for the personalization of sport training. Acta Biomed. 2020 Nov 9;91(13-S):e2020012. doi: 10.23750/abm.v91i13-S.10593. PMID: 33170162; PMCID: PMC8023127.
- Semenova EA, Hall ECR, Ahmetov II. Genes and Athletic Performance: The 2023 Update. Genes (Basel). 2023 Jun 8;14(6):1235. doi: 10.3390/genes14061235. PMID: 37372415; PMCID: PMC10298527.
- Pickering C, Kiely J. ACTN3: More than Just a Gene for Speed. Front Physiol. 2017 Dec18;8:1080. doi: 10.3389/fphys.2017.01080. PMID: 29326606; PMCID: PMC5741991.
- Sharples AP, Stewart CE, Seaborne RA. Does skeletal muscle have an 'epi'-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise. Aging Cell. 2016 Aug;15(4):603-16. doi: 10.1111/acel.12486. Epub 2016 Apr 22. PMID: 27102569; PMCID: PMC4933662.
- Semenova EA, Hall ECR, Ahmetov II. Genes and Athletic Performance: The 2023 Update. Genes (Basel). 2023 Jun 8;14(6):1235. doi: 10.3390/genes14061235. PMID: 37372415; PMCID: PMC10298527.
-Tarnowski M, Tomasiak P, Tkacz M, Zgutka K, Piotrowska K. Epigenetic Alterations in Sports-Related Injuries. Genes (Basel). 2022 Aug 17;13(8):1471. doi: 10.3390/genes13081471. PMID: 36011382; PMCID: PMC9408207.
- Terrell TR, Bostick RM, Abramson R et al. APOE, APOE promoter, and Tau genotypes and risk for concussion in college athletes. Clin. J. Sport Med. 18(1), 10–17 (2008).
- Turner, D.C., Seaborne, R.A. & Sharples, A.P. Comparative Transcriptome and Methylome Analysis in Human Skeletal Muscle Anabolism, Hypertrophy and Epigenetic Memory. Sci Rep 9, 4251 (2019). https://doi.org/10.1038/s41598-019-40787-0
- Williams AG, Folland JP. Similarity of polygenic profiles limits the potential for elite human physical performance. J Physiol. 2008;586:113–21.