Showing titles in Genetics

Our understanding of the ‘tree of life’, with powerful implications for human genetics, human health and our own human nature, has recently completely changed. This book is about a new method of telling the story of life on earth - through molecular phylogenetics. It involves a fairly simple method - the reading of the deep history of life by looking at the variation in protein molecules found in living organisms. For instance, we now know that roughly eight percent of the human genome arrived not through traditional inheritance from directly ancestral forms, but sideways by viral infection.

Since the dawn of humankind, mental illness has been one of our greatest causes of suffering as a species. But for the majority of our history, its causes have remained a mystery. Professor Karl Deisseroth shares his breakthrough discovery, optogenetics, a biological technique that allows us to decipher the brain's inner workings using light. With moving and revelatory stories from both personal and professional experience, he reveals what mental illnesses really are, why we suffer from them and the unexpected role they have played in our evolution.

Scientists' understanding of life is progressing more rapidly than at any point in human history, from the extraordinary decoding of DNA to the controversial emergence of biotechnology. Featuring pioneering biologists, geneticists, physicists, and science writers, Life explains just how far we've come - and takes a brilliantly educated guess at where we're heading.

This is a story about you. It is the history of who you are and how you came to be. It is unique to you, as it is for every one of the 100 billion modern humans who has ever drawn breath. But it is also our collective story, because in each of our genomes we carry the history of the whole of our species.

Epigenetics is the science of living DNA, charting the chemical pathways that spur DNA into action by turning genes on and off. While the Human Genome Project of the early 2000s was hailed as the key to understanding human heredity and disease, that historic effort was just the beginning. It has taken epigenetics to fill in the picture, explaining how the fixed code of our genome is implemented in countless living processes.

Over 500,000 years ago, a single gene mutated. It spread over time, becoming critical in the journey transforming our earliest ancestors into fully modern humans, capable of navigating the entire planet and beyond. Then just a few thousand years ago, humans gradually outsourced knowledge to writing, and we displaced art and music from the heart of learning. This is the extraordinary story of the discovery of a supergene that makes us uniquely human.

Fifty thousand years ago, we were not the only species of human in the world. There were at least four others, including the Neanderthals, Homo floresiensis, Homo luzonesis and the Denisovans. At the forefront of the latter's ground-breaking discovery was Oxford Professor Tom Higham. In The World Before Us, he explains the scientific and technological advancements.

Nothing is more familiar and yet less understood than the human mind. It defines the experience of being human, and yet its workings contain some of the deepest mysteries ever encountered. Written by one of the world's greatest teachers of psychology, The Human Mind provides a masterful and riveting guide to all that we have learned since modern science began probing those mysteries.

In this ground-breaking and entertaining exploration of athletic success, award-winning writer David Epstein gets to the heart of the great nature vs. nurture debate, and explodes myths about how and why humans excel. Along the way, Epstein exposes the flaws in the so-called 10,000-hour rule that states that rigorous practice from a young age is the only route to success.

A preeminent geneticist hunts the Neanderthal genome to answer the biggest question of them all: what does it mean to be human? What can we learn from the genes of our closest evolutionary relatives? Neanderthal Man tells the story of geneticist Svante Pbo’s mission to answer that question, beginning with the study of DNA in Egyptian mummies in the early 1980s and culminating in his sequencing of the Neanderthal genome in 2009.

All of us would like to live longer, or to slow the debilitating effects of age. In How We Age, Coleen Murphy shows how recent research on longevity and aging may be bringing us closer to this goal. Murphy, a leading scholar of aging, explains that the study of model systems, particularly simple invertebrate animals, combined with breakthroughs in genomic methods, have allowed scientists to probe the molecular mechanisms of longevity and aging.

She Has Her Mother’s Laugh presents a profoundly original perspective on what we pass along from generation to generation. Charles Darwin played a crucial part in turning heredity into a scientific question, and yet he failed spectacularly to answer it. The birth of genetics in the early 1900s seemed to do precisely that. Gradually, people translated their old notions about heredity into a language of genes. As the technology for studying genes became cheaper, millions of people ordered genetic tests to link themselves to missing parents, to distant ancestors, to ethnic identities....

World renowned scientist Carl Sagan and acclaimed author Ann Druyan have written a Roots for the human species, a lucid and riveting account of how humans got to be the way we are. It shows with humor and drama that many of our key traits - self-awareness, technology, family ties, submission to authority, hatred for those a little different from ourselves, reason, and ethics - are rooted in the deep past, and illuminated by our kinship with other animals.

James D. Watson, the Nobel laureate whose pioneering work helped unlock the mystery of DNA's structure, charts the greatest scientific journey of our time, from the discovery of the double helix to today's controversies to what the future may hold. Updated to include new findings in gene editing, epigenetics, and agricultural chemistry as well as two entirely new chapters on personal genomics and cancer research. This is the most comprehensive and authoritative exploration of DNA's impact on our society and our world.

Nessa Carey’s The Epigenetics Revolution looks at how modern biology is rewriting our understanding of genetics, disease and inheritance....

Brian and Deborah Charlesworth provide a clear and concise summary of the process of evolution by natural selection, and how natural selection gives rise to adaptations and eventually, over many generations, to new species. They introduce the central concepts of the field of evolutionary biology, as they have developed since Darwin and Wallace on the subject, over 140 years ago, and discuss some of the remaining questions regarding processes.

Humanity has often found itself on the precipice. We've survived and thrived because we've never stopped moving. In this eye-opening book, Johannes Krause, chair of the Max Planck Institute for the History of Humanity, offers a new way of understanding our past, present and future. Marshalling unique insights from archaeogenetics, an emerging new discipline that allows us to read our ancestors' DNA like journals chronicling personal stories of migration, Krause charts two millennia of adaption, movement and survival.

Perched on the exterior of our delicate and intricate bodies, the skin is our largest and fastest growing organ. We see it, touch it and live in it every day. It's a habitat for a mesmerisingly complex world of micro-organisms, its physical functions are vital to our health and indeed our survival, and it's crucial to our sense of identity. Yet how much do we really know about it? Through the lenses of science, sociology and history, Dr Monty Lyman leads us on a journey through the comedy, tragedy and exquisite humanity of our most underrated and overlooked organ.

Geneticists like David Reich have made astounding advances in the field of genomics, which is proving to be as important as archaeology, linguistics, and written records as a means to understand our ancestry. In Who We Are and How We Got Here, Reich allows listeners to discover how the human genome provides not only all the information a human embryo needs to develop but also the hidden story of our species.

What makes you the way you are - and what makes each of us different from everyone else? In Innate, leading neuroscientist and popular science blogger Kevin Mitchell traces human diversity and individual differences to their deepest level: in the wiring of our brains.