• World's First Malaria Vaccine Endorsed by WHO for Widespread Use in Sub-Saharan Africa

  • Oct 26 2024
  • Length: 3 mins
  • Podcast

World's First Malaria Vaccine Endorsed by WHO for Widespread Use in Sub-Saharan Africa

Listen for free

View show details

  • Summary

  • In a monumental breakthrough in global health, RTS,S/AS01 (RTS,S), the world’s first malaria vaccine, has been endorsed by the World Health Organization for widespread use among children in sub-Saharan Africa and other regions with moderate to high Plasmodium falciparum malaria transmission. This recommendation, made in late 2021, marks a significant milestone in the fight against a disease that has plagued humanity for centuries.

    Malaria, caused by Plasmodium parasites transmitted through the bites of infected female Anopheles mosquitoes, remains one of the leading causes of illness and death in many developing countries. According to the World Health Organization's World Malaria Report 2021, there were an estimated 241 million cases of malaria worldwide in 2020, leading to 627,000 deaths. The majority of these cases and deaths were in Africa, and children under five years of age are the most vulnerable group, accounting for about 80% of all malaria deaths in the region.

    The RTS,S vaccine, developed by GlaxoSmithKline over several decades with support from PATH and in partnership with the Bill and Melinda Gates Foundation, offers a substantial ray of hope. Known scientifically as RTS,S/AS01E, the vaccine acts against Plasmodium falciparum, the most deadly malaria parasite globally and the most prevalent in Africa. Clinical trials have shown that the vaccine has a protective efficacy of about 30% against severe malaria in the trials conducted with African children.

    The endorsement by the World Health Organization followed a pilot program launched in 2019 in Ghana, Kenya, and Malawi that reached more than 800,000 children. The program demonstrated that the vaccine is safe, feasible to deliver, and has a significant impact on preventing severe cases of malaria. Consistently, it reduces severe, life-threatening malaria by approximately 30%, an impressive achievement given the complexity of the parasite and its ability to evade immune responses.

    This vaccine is a complementary malaria control tool to be added to the current toolkit, which includes long-lasting insecticide-treated bed nets, indoor spraying with insecticides, and timely access to malaria testing and treatment. The RTS,S vaccine is particularly crucial as malaria resistance to treatment and prevention methods continues to pose challenges in many parts of the world.

    The implementation of the RTS,S vaccine is being scaled up to save more lives. This deployment, along with continued efforts in vaccine research, could pave the way for even more effective second-generation malaria vaccines. Investments in malaria prevention and treatment are crucial for a broad public health strategy, especially in sub-Saharan Africa, where the burden of the disease is heaviest.

    The development and deployment of RTS,S are indeed a historic moment in the battle against malaria, promising to save tens of thousands of lives each year. The global health community remains cautiously optimistic, hopeful that this is just the beginning of the end of malaria’s reign of terror in vulnerable regions.
    Show More Show Less
Show More Show Less
activate_Holiday_promo_in_buybox_DT_T2

What listeners say about World's First Malaria Vaccine Endorsed by WHO for Widespread Use in Sub-Saharan Africa

Average customer ratings

Reviews - Please select the tabs below to change the source of reviews.

Audible.co.uk reviews

Amazon reviews
No Reviews are Available