What happens to your body when you stop moving? While most people think of metabolism as something that just runs in the background burning calories, the truth is far more complex and fascinating. Your metabolism is constantly adapting to your activity levels - or lack thereof - in ways that can profoundly impact your health.

Join Holly and Jim as they welcome Dr. John Thyfault, Director of the KU Diabetes Institute and one of the world's leading researchers in metabolism, obesity, and exercise physiology. Together, they explore the intricate connection between movement and metabolism, revealing how even small changes in activity can have rapid effects on your body's ability to process nutrients and regulate energy.

• The surprising speed at which metabolism changes when you stop moving
• Why your genes aren't necessarily your metabolic destiny
• The truth about "slow" metabolism and what really impacts your metabolic health
• A game-changing perspective on exercise that turns conventional wisdom upside down
• The critical link between movement and insulin sensitivity that most people miss
• Why the new weight loss medications aren't a complete solution without movement
• Simple strategies to break up sedentary time that can improve your metabolism within hours
• The often-overlooked connection between movement and healthy aging

• Lowering physical activity impairs glycemic control in healthy volunteers
• Breaking up prolonged sitting reduces postprandial glucose and insulin responses
• Fitness and Fatness as Health Markers through the Lifespan: An Overview of Current Knowledge

Connect with Dr. John Thyfault on LinkedIn here: linkedin.com/in/john-thyfault-85312092

Making America healthy again sounds like a noble goal - but what would it actually take? With over 75% of U.S. adults overweight or obese and 60% battling chronic diseases, our nation's health is headed in the wrong direction.

Join Holly and Jim as they dive into this complex challenge, examining potential solutions and uncovering why quick fixes won't work. You'll discover why focusing on just one aspect - processed foods, exercise, or weight loss - isn't enough to turn the tide. Along the way, you'll learn about emerging opportunities and get an inside look at what a true "health moonshot" might require.

• Why putting a grocery store in a food desert isn't enough to change eating habits
• The surprising truth about who really uses workplace wellness incentives
• How the Mediterranean diet improves health - but falls short in one key area
• Why Europe's public transit system gets vacationers moving more
• The game-changing role of mindset in maintaining healthy behaviors
• What America's moonshot to space can teach us about transforming health
• The three non-negotiable pillars for making lasting health improvements

• Physical activity and coronary heart disease in men: The Harvard Alumni Health Study
• Physical activity patterns associated with cardiorespiratory fitness and reduced mortality: the Aerobics Center Longitudinal Study

Success stories inspire us not just because of the results achieved, but because they show us what's possible in our own lives. In this episode, we meet Amy, whose journey began with a simple goal to "lose a few pounds" but evolved into something far more meaningful.

What starts as a weight loss story transforms into a tale of rediscovering joy, embracing vulnerability, and finding unexpected adventures - including joining a cycling club at 64! Amy's candid sharing of her six-year journey reveals how weight loss isn't just about the number on the scale; it's about opening yourself to new possibilities and creating a life you don't want to step away from.

Discussed on the episode:

• The surprising mindset shift that turned "just another diet" into lasting change
• Why being the slowest cyclist in the group became a source of pride instead of shame
• How the fear of maintaining weight loss forever eventually fades away
• The unexpected way Amy's transformation inspired changes in her family
• The real reason Amy won't go back to her old lifestyle (it's not about the weight)
• What happened when COVID threw a curveball into Amy's maintenance journey