Paul Simms is the CEO of Impatient Health and a trailblazing voice in the life sciences industry. Paul is on a mission to push the boundaries of pharma. He works with innovators and early adopters to inject “mutation pressure” into the status quo, ensuring bold ideas and creative solutions make their way into the market. Drawing on his experience as a speaker, event organizer, and consultant, Paul discusses how pharma can evolve to truly align with patients’ needs. Together, with Maya they explore the intersection of innovation, behavioral science, and systemic transformation in healthcare.

What You’ll Learn:
- Why Paul believes the pharma industry is still in its infancy and how it can grow.
- What “mutation pressure” means and how it can drive innovation in pharma.
- The critical role of patient engagement and behavioral science in improving healthcare outcomes.
- How Paul’s work with major pharma companies has shaped his views on the future of the industry.
- Practical lessons from other industries, including fashion and tech, that pharma can adopt.

In this episode of Trials with Maya Z, Maya and patient expert and advocate Orit Rindner discuss the intersection of patient needs and clinical trials, highlighting real-world challenges and insights from rare disease research:

• The impact of standard of care on patient willingness to join clinical trials
• Challenges in rare disease trials and patient recruitment
• The importance of aligning clinical trials with patient realities

Follow Maya Zlatanova: https://www.linkedin.com/in/mayazlatanova/
Follow Orit Rindner: https://www.linkedin.com/in/oritrindner/

• (00:00) - Chapter 1
• (00:00) - Introduction to Clinical Research and Patient Advocacy
• (02:28) - The Intersection of Patient Advocacy and Clinical Trials
• (04:49) - Patient Perspectives on Clinical Trials
• (06:47) - Engagement of Patients in Clinical Trial Design
• (10:11) - Isolated vs multidisciplinary approach
• (12:27) - The Role of Patient Advocates in Clinical Research
• (16:12) - Impact of Current Events on Clinical Research in Israel

"Only 1-4% of global healthcare R&D funding is dedicated to female-specific conditions beyond cancer, despite women representing 51% of the population.” Meet Estelle Jobson - an EUPATI Fellow and a patient advocate living with endometriosis. In this episode, Maya and Estelle discuss the limitations of standard care for this chronic condition and call for research that addresses its diverse symptoms.

• Why Standard care for endometriosis fails to address patient needs?
• What is wrong with the current definition of endometriosis?
• What are the current treatment gaps?

Follow Maya Zlatanova: https://www.linkedin.com/in/mayazlatanova/
Follow Estelle Jobson: https://www.linkedin.com/in/estelle-jobson-27389821/

• (00:00) - Introduction and Background
• (02:00) - Lack of Funding for Women's Health Research
• (05:34) - Challenges in Diagnosing and Treating Endometriosis
• (09:23) - Limitations of Current Clinical Trials
• (15:57) - The Need for Fresh Perspectives in Endometriosis Research
• (25:47) - Including a Wider Range of Patients in Clinical Trials
• (30:15) - Addressing the Diverse Symptoms of Endometriosis
• (36:29) - Summary and Conclusion