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In this latest episode of The Incubator Podcast Journal Club, Ben and Daphna explore studies that may shift clinical practices in neonatal care. They begin with a study from India examining oral calcium phosphate as an adjunct to phototherapy in treating neonatal jaundice. This double-blind, randomized, placebo-controlled trial investigates how calcium phosphate may help reduce bilirubin levels by binding to unconjugated bilirubin in the gut, potentially minimizing the need for prolonged phototherapy. The findings suggest that calcium phosphate could lower phototherapy duration and decrease cases of rebound hyperbilirubinemia, offering a possible new approach for jaundiced newborns.

The episode also covers an intriguing study on alternative treatments for persistent pulmonary hypertension of the newborn (PPHN). By comparing oral sildenafil to bosentan, this research sheds light on the potential of sildenafil to reduce PASP more efficiently, especially in resource-limited settings. The team discusses these insights and examines how they may influence care for PPHN cases worldwide.

As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!