For this episode, we discuss the roles and sensitivity of mitochondria with Dr. Richard Frye, MD, PhD. Dr. Frye received an MD and a PhD in Physiology and Biophysics from Georgetown University. He is board certified in Pediatrics, Neurology with special competence in Child Neurology, and as a Certified Principal Investigator. In addition, he has a Masters in Biomedical Sciences and Biostatistics from Drexel University. Dr. Frye has over 300 publications in leading journals and book chapters.

He currently sees patients as a Neurologists and Director of Research at Rossingnol Medical Center and at Neurodevelopmental Precision Medicine. In 2022, Dr. Frye co-founded the Autism Discovery and Treatment Foundation where they are dedicated to discover biomarkers, metabolic endophenotypes, and treatments for neurodevelopemental disorders.

Dr. Frye shares many figures during the conversation so the listener can follow along.

Dr, Richard Frye https://drfryemdphd.com

CV https://wparticles.seek2understand.org/wp-content/uploads/2023/02/DrFryeCVJan2023.pdf

Rossingnol Medical Center Facebook https://www.facebook.com/RossignolMedicalCenter

Neurobiology of Disease 2024 paper https://www.sciencedirect.com/science/article/pii/S0969996124001190?via%3Dihub

Autism and GI, and exploring how changes in Light have major implications (Apple) https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000664349495

0:00 Dr. Richard Frye

6:13 Intro into mitochondria & energy production, various disease & dysfunction

11:16 Mitochondrial DNA, sensitivity, and the roles with epigenetics

16:16 Biomarkers of mitochondrial dysfunction, delicate delivery (space and time) into the electron transport chain

20:58 Cytochrome C Oxidase (complex IV); Carnitine, Fat, and Creatine

26:57 Molecules connected to aging & cellular respiration, environemental signals implicating mitochondria

30:26 Terrible Trio: oxidative stress, mitochondria dysfunction, immune/inflammation, DAMPS & inflammation

34:29 Environmental risks for the Embryo, overreactivity of mitochondria (200%) and physiological insults and regression

42:50 Tryptophan (aromatic amino acid), NAD, and Gastrointestinal biosynthesis

45:52 Light as an environmental change factoring into the Autistic Phenotype, Infant Tree and Adult Tree examples; Vitamin D (skin & brain are connected through Neuroectoderm)

54:54 Future Research

59:58 Wrap up, Reviews/Ratings

X: https://twitter.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: info.fromthespectrum@gmail.com

In this episode, we discuss the mitochondria. You know mitochondria as the "powerhouse" of the cell, but this biological process is biophysics meeting biochemistry. We discuss glycolysis, the TCA cycle (or Citric Acid cycle or Krebs cycle), and Oxidative Phosphorylation. This discussion goes deep inside the atomic molecular level with electrons and protons. Hang in there with the discussion and topic of Autism and understanding of the generational link to a loss of electrons.

Jack Kruse https://www.patreon.com/DrJackKruse/posts

Glycolysis https://www.ncbi.nlm.nih.gov/books/NBK470170/#:~:text=Glycolysis%20is%20a%20central%20metabolic,use%20in%20other%20metabolic%20pathways.

Citric Acid cycle https://en.wikipedia.org/wiki/Citric_acid_cycle

Oxidative Phosphorylation https://en.wikipedia.org/wiki/Oxidative_phosphorylation

0:00 Intro; Light, water, magnetism; The "powerhouse" and understanding of healthy living organisms and different cell types; Photosynthesis and Cell Respiration

4:11 Prokaryotes, Eukaryotes, and Cytochrome C Oxidase (CCO)

6:53 Mitochondria and Cellular Respiration 1) Glycolysis, 2) Citric Acid cycle, and 3) Oxidative Phosphorylation (OXPHOS)

8:25 Glycolysis

10:03 Citric Acid cycle

12:02 OXPHOS

13:51 Cytochrome I

15:07 Cytochrome II

16:08 Cytochrome III

17:10 Cytochrome IV and creating water

19:56 Not all water is equal/same; Aging; Light and Melanin and Rates of Autism

29:20 Cytochrome V and ATPase; Chromophores

33:56 Evolution and losing electrons; Autism and modern health complications

37:50 Environmental signals due DNA sequencing; Autism research and Genetic studies

40:23 Reviews/Ratings and contact info

X: https://twitter.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

email: info.fromthespectrum@gmail.com

In this episode, we challenge the modern trend of Autism and ADHD comorbid diagnosis. We will use children from Kanner and Asperger to show these so-called ADHD symptoms are simply parts of the Autistic Phenotype. However, society finds it easier to lump these two conditions together, and we question why. We review both, the inattentive criteria and the hyperactivity and impulsivity of ADHD and explain when the Autistic phenotype exhibit these conditions.

The criteria for ADHD are downstream behaviors seen across multiple reasons and act as a collect-all. I did not say ADHD does not exist, but I do say Autism and ADHD existing simultaneously seems unlikely if you really understand the phenotypes. Might it just be easier for society to lump these together instead of challenging the differences?

B.3 and Inattention are complete opposites. Hyperactivity and Impulsivity can show up when anyone is in the wrong or horrible environment.

Autism and ADHD https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918663/

Leo Kanner http://www.autismtruths.org/pdf/Autistic%20Disturbances%20of%20Affective%20Contact%20-%20Leo%20Kanner.pdf

Hans Asperger https://psycnet.apa.org/record/1992-97284-002

0:00 Intro; Brief Note on how environmental signals such as electromagnetic fields (EMF, i.e., Light) informs the genes on how to respond, and how disease manifests

2:51 Autism and ADHD; Neurodiversity; and some problems in society

7:58 Core of Autism- B.3, and Donald Triplett example; B.2 and Social Communication

13:27 Autistic Phenotypes

19:01 ADHD Phenotypes

21:41 Specifiers and Lumping Contrasting Phenotypes

33:18 Medication and ODD (Oppositional Defiant Disorder) Rant

35:42 Autism conundrum with ADHD

38:45 Reviews/Ratings and Contact Info

Hopp: https://www.hopp.bio/fromthespectrum

X: https://twitter.com/rps47586

email: info.fromthespectrum@gmail.com