• Diagnosing Cold Agglutinin Disease

  • Aug 30 2021
  • Length: 7 mins
  • Podcast

Diagnosing Cold Agglutinin Disease

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  • Summary

    • To identify potential patients, a diagnostic workup of AIHA is essential, including antibody type, patient history and physical exam, hemoglobin levels and blood cell counts, blood smear examination and direct antiglobulin test (DAT)
    • Diagnostic criteria for CAD include chronic hemolysis, polyspecific DAT positive, monospecific DAT strongly positive for C3d, CA titer ≥64 at 4°C and a bone marrow evaluation (advised in patients with CAD at diagnosis)
    • Hemoglobin is the most direct indicator of clinical severity
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