In this episode, listen to Virginia Kaklamani, MD, DSc; Erica L. Mayer, MD, MPH; and Laura M. Spring, MD, share their clinical insights and takeaways from a live symposium, including from key abstracts presented at the 2024 San Antonio Breast Cancer Symposium:

• Estrogen Receptor Mutations in Patients With HR-Positive/HER2-Negative Advanced Breast Cancer
• Current Guideline Recommendations for When to Pursue ESR1 Mutation Testing Mutations in Patients With HR-Positive/HER2-Negative Advanced Breast Cancer
• Choice and Sequencing of Next Line of Systemic Therapy for ESR1-Mutated Advanced Breast Cancer Based on Tumor Molecular Alterations
• Overview of Class-Related and Unique Adverse Events With Approved and Emerging Oral SERDS
• Expert Recommendations for the Management of Oral SERDs-Related Adverse Events

Program faculty:

Virginia Kaklamani, MD, DSc
Professor of Medicine
Ruth McLean Bowman Bowers Chair in Breast Cancer Research and Treatment
A.B. Alexander Distinguished Chair in Oncology
Leader
Breast Oncology Program
UT Health San Antonio
MD Anderson Cancer Center
San Antonio, Texas

Erica L. Mayer, MD, MPH
Director of Breast Cancer Clinical Research
Dana-Farber Cancer Institute
Associate Professor in Medicine
Harvard Medical School
Boston, Massachusetts

Laura M. Spring, MD
Breast Medical Oncologist
Mass General Hospital Cancer Center
Harvard Medical School
Boston, Massachusetts

Resources:
To download the slides associated with this podcast discussion, please visit the program page.

In this episode, Caitlin Costello, MD, discusses important topics related to relapsed/refractory (R/R) multiple myeloma (MM), including:

• 3 bispecific antibodies approved for the treatment of R/R MM that target BCMA or GPRC5D
• The role of bispecific antibodies in R/R MM
• Safety considerations for patients while receiving a bispecific antibody
• Emerging data and clinical trials with bispecific antibodies
• Key clinical pearls for optimal use of bispecific antibodies

Presenter:

Caitlin Costello, MD
Clinical Professor of Medicine
Director, Multiple Myeloma Program
Division of Blood and Marrow Transplantation
Moores Cancer Center
UC San Diego
La Jolla, California

Link to full program:
https://bit.ly/40bjFCZ

In this episode, Thor R. Halfdanarson, MD, and Jonathan Strosberg, MD, discuss important topics related to gastroenteropancreatic neuroendocrine tumors (GEP-NETs), including:

• The diagnosis and typical presenting symptoms of GEP-NETs
• Findings from recent key phase III studies including NETTER-2 and CABINET
• Recommendations for treatment sequencing
• Notable clinical pearls regarding GEP-NET therapies
• Current guidelines for GEP-NET care and monitoring

Presenters:

Thor R. Halfdanarson, MD
Consultant, Division of Medical Oncology
Professor of Oncology
Associate Professor of Medicine
Mayo Clinic Comprehensive Cancer Center
Chair, Hepato-Pancreatico-Biliary Disease Group
Rochester, Minnesota

Jonathan Strosberg
Professor, GI Oncology
Chair, Neuroendocrine Tumor Division
Moffitt Cancer Center and Research Institute
Tampa, Florida

Link to full program:
https://bit.ly/3Y0JWBa