In this episode, I talked with Dr. Leila Jaffar, CEO of Nuclidium, where she shares her journey from a childhood influenced by her father's passion for science to becoming a leader in the biotech industry. She discusses the challenges she faced during her career, including personal and professional, and her transition from academia to industry. Leila elaborates on the mission of Nuclidium, focusing on the development of copper-based diagnostics and therapeutics for oncology. She also emphasizes the importance of company culture, the impact of every team member, and the lessons learned in leadership and hiring.

Here's what you're in:

• What is the goal with Nuclidium?
• How can networking becomes crucial for career advancement?
• Why did you decide to go down the founder route?

Timestamps:

02:08 Journey into Life Sciences

04:26 Dealing With Career's Lowest Point

09:31 Getting A Job After Finishing PhD

11:09 Founding of her Own Company

14:37 Nuclidium and What Sets It Apart

21:55 Why Join Nuclidium - What is its Culture?

24:22 Lessons Learned Through Hiring and Managing People

27:38 Quickfire Questions

About Leila

Dr. Leila Jaafar, CEO of Nuclidium, a clinical-stage radiopharmaceutical working on copper-based diagnostics and therapeutics. Dr. Leila is also the co-founder of LinaThera, which is partnered with Nuclidium and focuses on the production of medical radionuclides. Prior to joining Nuclidium, she was the CEO of Swiss Nuclides for 5 years and Program Manager at Areva for 6 years. Outside of her professional role, she plays the violin and loves to read in her free time.

Connect with Leila

LinkedIn: https://www.linkedin.com/in/leila-jaafar-605642130/

Company Website: https://nuclidium.com/

About Me

My name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.

In 2023, I decided to launch his firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.

Connect with me:

LinkedIn: https://www.linkedin.com/in/charles-spence-clinical/

Website: https://www.discera-search.com/

Opinions and comments expressed by the guest do not represent the company and are fully their own.

In this episode, I talked with Roger Waltzman, Chief Medical Officer at Indaptus Therapeutics, discussing his career, overview of Indaptus, the development of Indaptus’ lead candidate, and the challenges of cancer treatment. We explore the benefits of a multi-targeted approach in immunotherapy, the story, and the lessons he learned from the failed Phase 3 trial of Vadimezan. Roger also serves as a Board of a non-profit organization called GoDocGo which provides low-cost cervical cancer screening in low-middle income countries and its impact.

Here's what you're in:

• What are other lessons from the Vadimezan Phase III failure?
• What is unique about Indaptus?
• Why are so few companies focused on multi-targets and instead focus mostly on targeted therapy?

Timestamps:

00:38 Introduction and Career Background

02:16 About Indaptus' Broad Immune Stimulant

05:08 Advantages of a Broad, Multi-Targeted Approach

10:08 Why Companies Don't Do Broad, Multi-Targeted Approach

13:44 Vadimezan and its Science

16:06 Learning Experiences from Clinical Trials of Vadimezan

21:58 Insights About Rushing the Trials into Phase III

26:53 GoDocGo: Inexpensive Cervical Cancer Screening

About Roger

Roger Waltzman is a Chief Medical Officer at Indaptus Therapeutics, where he leads the Phase 1a/b immuno-oncology program. Indaptus develops anti-cancer and anti-viral immunotherapy products, with its lead candidate, Decoy20, currently in Phase 1 trials. Indaptus' proprietary platform utilizes non-pathogenic bacteria and has patent protection in 32 countries. Before Indaptus, Dr. Waltzman held CMO roles at Molecular Templates and RegenX (now Inspirna), and he spent nine years at Novartis, where he led clinical development teams, including the Jakavi collaboration. Dr. Waltzman also holds an MD from Brown and an MBA from Columbia. He serves as a Board of a non-profit organization called GoDocGo which provides low-cost cervical cancer screening.

Connect with Roger

LinkedIn: https://www.linkedin.com/in/roger-waltzman-021bb91/

Company Website: https://indaptusrx.com/

Organization: https://www.godocgo.org/

About me

My name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.

In 2023, I decided to launch his firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.

Connect with me:

LinkedIn:https://www.linkedin.com/in/charles-spence-clinical/

Website: https://www.discera-search.com/

Opinions and comments expressed by the guest do not represent the company and are fully their own.

In this episode, I spoke with Gertjan Bartlema, the co-founder Populus Bio and CEO of Immodulon Therapeutics. Over 20 years in big pharma at Celgene/Amgen and then moved into the fast pace world of biotech. From here, he has been challenging the status quo and asking the question “Is our current drug development approaches sustainable?”. Gertjan highlights the need for better clinical trial designs and the importance of making objective decisions based on data. He also offers valuable insights for aspiring executives on leadership and team dynamics.

Here's what you're in:

• How many drugs fail end-points due to Bad Leadership?
• Why does Gertjan believe sequential and traditional drug Development can kill innovation within Drug Development?.
• What advice does Gertjan give to those wanting to become a CEO?

Timestamps:

02:53 The Abraxane Course Correction

06:03 Gertjan’s Journey into Life Sciences

10:40 Leaving Celgene and New Ventures

15:50 Bayesian Statistics in Clinical Studies

19:27 Mistakes Companies Are Still Making Today

25:38 The Ambitious People

35:46 Advice for Aspiring Executives

About Gertjan

Gertjan Bartlemais co-founder of Populus Bio and current CEO of Immodulon Therapeutics which is running cancer trials focusing on a broad spectrum immunomodulator. He is a global biotech executive with extensive experience in EU and US operational roles and he is a member of founding Celgene EMEA management establishing EU footprint and launching Revlimid. Prior to joining Immodulon, he was the Chief Business Officer of Vico Therapeutics, and spent 12 years with Celgene, where he led the trial of Revlimid. Gertjan holds MSc in Economics from Maastricht University.

Connect with Gertjan

LinkedIn: https://www.linkedin.com/in/gertjan-bartlema/

Populus Bio: https://populusbio.com/

Immodulon Therapeutics: https://www.immodulon.com/

About me

My name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.

In 2023, I decided to launch his firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.

Connect with me:

LinkedIn:https://www.linkedin.com/in/charles-spence-clinical/

Website: https://www.discera-search.com/

Opinions and comments expressed by the guest do not represent the company and are fully their own.