Join Matt today as he explores the fascinating intersection of sleep, metabolism, and weight management, delving into the science of dual orexin receptor antagonists (DORAs). This episode dissects a groundbreaking study on suvorexant (Belsomra), an FDA-approved insomnia medication, and its potential to enhance fat burning during sleep. Matt unpacks the role of orexin, a neuropeptide crucial for wakefulness, and explains how DORAs work by targeting orexin receptors to promote natural sleep.

This preliminary research, conducted on healthy young men, reveals suvorexant's intriguing ability to not only improve sleep quality, but also increase fat oxidation while preserving muscle mass. While these initial findings are promising, Matt emphasizes the importance of cautious optimism and the need for further research in more diverse groups. He explores the implications for weight management and metabolic health, highlighting the potential of suvorexant as a novel approach to weight loss. However, Matt underscores that a holistic approach, including diet, exercise, and good sleep hygiene, remains essential for long-term success. Tune in today to gain valuable insights into the complex relationship between sleep and metabolism, and how scientific advancements may pave the way for innovative solutions in weight management.

Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.

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As always, if you have thoughts or feedback you’d like to share, please reach out to Matt on Instagram.

Matt: Instagram @drmattwalker or on X @sleepdiplomat